Meet Dr. Meizi Eliezer: Leading the Way in Periodontal Advancements with Cross-Linked Hyaluronic AcidDr Meizi Eliezer portrait

REGEDENT interviewed Dr. Eliezer on using cross-linked hyaluronic acid hyaDENT BG in periodontal treatment and GBR. Dr. Meizi Eliezer is a reknowned periodontist accredited by the European Federation of Periodontology. She specialised at the university in Bern Switzerland. Today, Dr. Meizi runs a private clinic and continues her research in the field of Periodontology and cross-linked Hyaluronic Acid. You can read the full interview with Dr Eliezer below. 


Read the full interview below.

Dr. Meizi Eliezer : Interview about cross-linked hyaluronic acid in periodontal treatment and GBR

Thank you for meeting us here today Dr. Eliezer. You have worked extensively with cross-linked hyaluronic acid in periodontal treatment and GBR for many years.

Question 1: Can you tell us more about the clinical advantages that you see when using the cross-linked hyaluronic acid, hyaDENT BG in periodontal treatment?

Dr. Meizi Eliezer : “When you apply cross-linked hyaluronic acid into the periodontal pocket, it can help to accelerate the healing process of the pocket. Additonally, if you want to perform periodontal regeneration by mixing a bone graft and cross-linked hyaluronic acid, it makes the coagulum more stable. Together with HA the healing process will also be accelerated. We documented that when we applied cross-linked hyaluronic acid, it has a lasting effect that helps the osteoblasts to actually accelerate and proliferate better.


For me, as a clinician, I want to be able to stabilize the blood clot and to facilitate the healing. The direct benefit that I see for the patient is based on the feedback I get that they do not experience any pain and that in fact they feel great. Usually, after one week, when I have the suture removed, I see the wound healing better than what I saw before I started to using HA.”

Question 2: Does cross-linked hyaluronic acid, hyadent BG, present some interest in combination with collagen membrane?

Dr. Meizi Eliezer : “In dentistry, when we want to do a GBR, guided bone regeneration, or a GTR, guided tissue regeneration, we have to use a collagen membrane. One of the problems we face today is that we do not know if the membrane has degraded too fast or not. We would prefer it the the membrane stays as long as possible, in order that the bone that will reform under the membrane will be established.

So when we dip the collagen membrane in a crosslinked hyaluronic acid, we are actually able to prolong its staying above the wound. We get a better wound healing. We have shown in the literature that when we dip the membrane in crosslinked hyaluronic acid, we see that the membrane degrades slower and gains better wound healing.The healing will be faster and the bone will be regenerated better under the membrane.”

Question 3: Can you tell us more about your clinical experience with hyaDENT BG in GBR ?

Dr. Meizi Eliezer : “I have been working with cross-linked hyaluronic aci, hyaDENT BG for 8 years now and applying it in GBR. The guided bone regeneration always needs two components. They need the membrane and they need the bone. When we are using a membrane and some bone together one of the problem is if the membrane gets exposed to the oral cavity. Then the membrane would degrade faster and the bone is exposed faster. That means that the healing will not be as good as we would like it to be.

Now when we add in crosslinked hyaluronic acid, we are doing two things. One, we are prolonging the presence of the membrane. It degrades slower, as we have proven in the literature that the amount of macrophages is reduced in an environment with cross-linked hyaluronic acid. That means that it pushes away the macrophages that degrade the collagen membrane. Second, by dipping the membrane in hyaluronic acid and mixing bone with crosslinked hyaluronic acid, we facilitate the blood clot stabilization in the wound, and it means that we will gain faster bone healing. That means a better GBR procedure.”

 

Question 4: Do you think cross-linked hyaluronc acid should be used more frequently in surgical and non-surgical periodontal therapy?

Dr. Meizi Eliezer : “Yes , I believe it should be. I use crosslink hyaluronic acid in every surgery. Whether it is in non-surgical and surgical periodontal treatment. I like to use it together when I start my scaling and root planing, in a non-surgical manner. I see better results after three months. I’m also using it in surgical periodontal regenerative procedures, in GBR procedures, in sinus lifts, and also in recession coverage procedures.

So in all these procedures, I’m using cross-linked hyaluronic acid in order to facilitate the healing. When the healing is facilitated, the patient experiences far less pain.The healing is faster and the results are much better. Also, we don’t have any rejection by the body, and we don’t have any adverse effects because this is a natural material. Your body already knows hyaluronic acid, so it treats it as something of its own. So, I definitely think that it’s something that we should consider using more frequently in dentistry.”

 

Dr. Meizi Eliezer : Webinar & Lectures

Hyaluronic acid (HyA) is recognized as an adjuvant treatment for chronic inflammatory disease in addition to its use to improve healing after dental procedures.

The biological activity of cross-linked hyaluronic acid (xHyA – Hyadent BG) has been well-researched during the past decades; hyaluronic acid is a safe and easy-to-use biological agent; due to its wide array of properties, it may significantly improve the results of periodontal therapy. I use cross-linked hyaluronic acid gel in case of gingival recessions, infrabony defects, furcation, coronal lengthening, guided bone regeneration (GBR).

In the following webinar, we will go throw different dental surgery procedures and when the cross-linked hyaluronic acid (Hyadent BG) gel is found to be beneficial. In my experience, it is an essential material to promote healing and regeneration.

 

Dr. Meizi Eliezer : Publications in relation to cross-linked hyaluronic acid gel

  • Eliezer M, Imber JC, Sculean A, Pandis N, Teich S. Hyaluronic acid as adjunctive to non-surgical and surgical periodontal therapy: a systematic review and meta-analysis. Clin Oral Investig. 2019 Sep;23(9):3423-3435. doi: 10.1007/s00784-019-03012-w. Epub 2019 Jul 23. PMID: 31338632.
  • Eliezer M, Sculean A, Miron RJ, Nemcovsky C, Weinberg E, Weinreb M, Zoabi H, Bosshardt DD, Fujioka-Kobayashi M, Moses O. Hyaluronic acid slows down collagen membrane degradation in uncontrolled diabetic rats. J Periodontal Res. 2019 Dec;54(6):644-652. doi: 10.1111/jre.12665. Epub 2019 Jun 12. PMID: 31190426.
  • Guldener K, Lanzrein C, Eliezer M, Katsaros C, Stähli A, Sculean A. Treatment of single mandibular recessions with the modified coronally advanced tunnel or laterally closed tunnel, hyaluronic acid, and subepithelial connective tissue graft: a report of 12 cases. Quintessence Int. 2020;51(6):456-463. doi: 10.3290/j.qi.a44492. PMID: 32368762.
  • Ramanauskaite E, Machiulskiene V, Dvyliene UM, Eliezer M, Sculean A. Clinical Evaluation of a Novel Combination of Sodium Hypochlorite/Amino Acid and Cross-linked Hyaluronic Acid Adjunctive to Non-surgical Periodontal Treatment: A Case Series. Oral Health Prev Dent. 2023 Jul 13;21(1):279-284. doi: 10.3290/j.ohpd.b4347453. PMID: 37724897.
  • Asparuhova MB, Kiryak D, Eliezer M, Mihov D, Sculean A. Activity of two hyaluronan preparations on primary human oral fibroblasts. J Periodontal Res. 2019 Feb;54(1):33-45. doi: 10.1111/jre.12602. Epub 2018 Sep 27. PMID: 30264516; PMCID: PMC6586051.
  • Eliezer M, Sculean A, Miron RJ, Nemcovsky C, Bosshardt DD, Fujioka-Kobayashi M, Weinreb M, Moses O. Cross-linked hyaluronic acid slows down collagen membrane resorption in diabetic rats through reducing the number of macrophages. Clin Oral Investig. 2022 Mar;26(3):2401-2411. doi: 10.1007/s00784-021-04206-x. Epub 2021 Oct 4. PMID: 34608575.