hyaDENT BG – Dental Tissue Regenerator


hyaDENT BG is a sterile gel of highly purified cross-linked hyaluronic acid registered as a medical device (class III).

Syringe with 27G needle of hyadent BG


1,0 ml hyaDENT BG contains :

  • Hyaluronic acid : 2.0 mg
  • Hyaluronic acid cross-linked : 16.0 mg
  • Sodium chloride : 6.9 mg
  • Water for injection ad : 1.0 ml
  • Conserve at room temperature


  1. Bachar A. Husseini , Anton Friedmann , Ralph A. Wak , Nabil E. Ghosn , Georges Khoury , Tala EL Ghoul , Chloe Karen Abboud , Ronald J. Younes , Clinical and radiographic assessment of cross-linked hyaluronic acid addition in demineralized bovine bone based alveolar ridge preservation: A human randomized split-mouth pilot study, Journal of Stomatology oral and Maxillofacial Surgery (2023), doi: https://doi.org/10.1016/j.jormas.2023.101426
  2. Diehl, D.; Friedmann, A.; Liedloff, P.; Jung, R.M.; Sculean, A.; Bilhan, H. Adjunctive Application of Hyaluronic Acid in Combination with a Sodium Hypochlorite Gel for Non-Surgical Treatment of Residual Pockets Reduces the Need for Periodontal Surgery—Retrospective Analysis of a Clinical Case Series. Materials 2022, 15, 6508. https:// doi.org/10.3390/ma15196508
  3. Nobis, B.; Ostermann, T.; Weiler, J.; Dittmar, T.; Friedmann, A. Impact of Cross-Linked Hyaluronic Acid on Osteogenic Differentiation of SAOS-2 Cells in an Air-Lift Model. Materials 2022, 15, 6528.
  4. Božić D, Ćatović I, Badovinac A, Musić L, Par M, Sculean A. Treatment of Intrabony Defects with a Combination of Hyaluronic Acid and Deproteinized Porcine Bone Mineral. Materials (Basel). 2021 Nov 11;14(22):6795. doi: 10.3390/ma14226795. PMID: 34832196; PMCID: PMC8624958.
  5. Shirakata Y, Imafuji T, Nakamura T, Shinohara Y, Iwata M, Setoguchi F, Noguchi K, Sculean A. Cross-linked hyaluronic acid gel with or without a collagen matrix in the treatment of class III furcation defects: A histologic and histomorphometric study in dogs. J Clin Periodontol. 2022 Oct;49(10):1079-1089. doi: 10.1111/jcpe.13694. Epub 2022 Jul 21. PMID: 35817414; PMCID: PMC9796036.
  6. Shirakata Y, Imafuji T, Nakamura T, Kawakami Y, Shinohara Y, Noguchi K, Pilloni A, Sculean A. Periodontal wound healing/regeneration of two-wall intrabony defects following reconstructive surgery with cross-linked hyaluronic acid-gel with or without a collagen matrix: a preclinical study in dogs. Quintessence Int. 2021;0(0):308-316. doi: 10.3290/j.qi.b937003. PMID: 33533237.
  7. Pilloni A, Rojas MA, Marini L, Russo P, Shirakata Y, Sculean A, Iacono R. Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial. Clin Oral Investig. 2021 Aug;25(8):5095-5107. doi: 10.1007/s00784-021-03822-x. Epub 2021 Feb 10. PMID: 33565017; PMCID: PMC8342388.
  8. Eliezer M, Imber JC, Sculean A, Pandis N, Teich S, ‘Hyaluronic acid as adjunctive to non-surgical and surgical periodontal therapy: a systematic review and meta-analysis’, Clin O Inv 2019; doi: s00784-019-03012-w
  9. Asparuhova M, Kiryak D, Eliezer M, Mihov D, Sculean A. ‘Activity of two hyaluronan preparations on primary human oral fibroblasts’.J Periodontal Res 2018 Sep 27. Epub 2018 Sep 27
  10. Asparuhova M, Chappuis V, Stähli A, Buser D, Sculean A, ‘Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts, Clin Oral Investig. 2020 Mar 31. doi: 10.1007/s00784-020-03259-8.
  11. Eliezer M, Sculean A, Miron RJ, et al. ‘Hyaluronic acid slows down collagen membrane degradation in uncontrolled diabetic rats.’J Periodontal Res. 2019;00:1–9. https://doi.org/10.1111/jre.12665
  12. Pilloni A, Nardo F, Rojas MA. Surgical Treatment of a Cemental Tear‐Associated Bony Defect Using Hyaluronic Acid and a Resorbable Collagen Membrane: A 2‐Year Follow‐Up. Clinical Advances in Periodontics, Vol. 9, No. 2, June 2019 doi: 10.1002/cap.10053
  13. Fujioka-Kobayashi M, Müller H, Mueller A, Lussi A, Sculean A, Schmidlin PR, Miron RJ ‘In vitro effects of hyaluronic acid on human periodontal ligament cells’ BMC Oral Health (2017) 17:44 DOI 10.1186/s12903-017-0341-1
  14. Mueller A, Fujioka-Kobayashi M, Mueller HD, Lussi A, Sculean A, Schmidlin PR, Miron RJ. ‘Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading’ Clinical Oral Investigations 2016 May .DOI 10.1007/s00784-016-1856-6