Biological effect of hyaluronic acid on tissue regeneration

Regenerative growth factors and bioactive modifiers have increasingly become more utilized in daily clinical practice owing to their ability to speed tissue regeneration and decrease patient morbidity. One modality with great regenerative potential is that of Hyaluronic acid (HYADENT) which is a molecule highly expressed in periodontal tissues during embryogenesis that has been shown to lead to scarless wound healing. Owing to its elevated expression in periodontal tissues during development, its regenerative properties have recently been made commercially available with a number of pre-clinical and clinical studies evaluating its use for both hard and soft tissue regeneration. This talk will highlight the basic scientific background investigating the mode of action of hyaluronic acid during tissue regeneration, will outline a series of pre-clinical studies conducted to date, and present data from various systematic reviews highlighting its use in dental applications.