The CLEAN&SEAL concept was developed on the basis of scientific findings as a support for the closed treatment of periodontal and peri-implant inflammation and to minimize or avoid any further need for surgery.

In case of severe periodontitis and some peri-implantitis, CLEAN&SEAL is a two-step therapy for closed subgingival treatment (2) . The sequence of cleaning and sealing has shown the unique outcome to regenerate the tissues around the tooth/dental implant with a reduced need for surgery (3a) (3b) . The natural regenerative mechanism leads to much higher chances to preserve teeth and implant over time.

Treatment with CLEAN&SEAL can not only prevent the progression of the disease, but very often improve the health parameters, which were difficult to treat in the past. Even in “hopeless“ situations, a significant improvement of the situation can lead to preserving the tooth. As such, with CLEAN&SEAL, invasive surgical intervention can be avoided. CLEAN&SEAL achieves positive results through the regenerative stimulation of the cementum, periodontal ligament and alveolar bone. This leads to a shallower to shallower periodontal pocket and better tissue attachment to the tooth root.

Benefits of CLEAN&SEAL

  • Maintains your natural teeth/implant
  • Scientifically proven treatment
  • Reduces pain after the treatment
  • Materials of non-animal origin
  • Reduced costs compared to surgical procedure

Untreated Periodontitis vs Outcome after CLEAN&SEAL

  1. Bacterial biofilm
  2. Inflamed sulcus
  3. Deep inflamed/infected pocket
  4. Resorbed bone
  5. Resorbed cementum and periodontal ligament

Why use clean and seal

First, use the CLEANER

Why use the CLEANER?

A germ-free environment is a basic prerequisite for successful lasting treatment in wound healing. The CLEANER helps to remove subgingival deposits and granulated tissues and sim- plifies the mechanical treatment, e.g. with scalers or ultrasonic instruments.

Studies and clinical case series have shown that when the CLEANER is used in addition to non-surgical treatment, the pocket depth of teeth or implants can be reduced. The CLEANER is applied several times into the pocket around the tooth or implant before the subgingival cleaning process.

What is the CLEANER made of?

The cleaning gel consists of two components, a low-dose sodium hypochlorite (NaOCl) solution and an amino acid solution.
Both components are mixed before use.

Are side effects known?

Due to its special composition, the cleaning gel acts specifically on infected tissue without affecting healthy tissue. Thus, treat- ment with the CLEANER is very well tolerated. Direct swallowing of the preparation may cause a slight burning sensation in the mouth and throat.

Untreated Periodontitis vs Outcome after CLEAN

  1. Clean from biofilm
  2. Healthy sulcus
  3. Shallower healthy pocket
  4. Bone is still resorbed
  5. Cementum & periodontal ligament gain

Periodontitis after CLEAN

And then, use the SEALER.

Why use the SEALER?

The SEALER consists of cross-linked hyaluronic acid. Its diverse properties, xHyA performs a whole range of different functions. For application in dentistry, the following three properties are particularly noteworthy

Better and faster wound healing

Every healing process begins with the attraction and stabilisation of the blood coagulum in the wound. This blood contains essential growth factors stimulating the regeneration of different tissues. Rapidly, the inflammatory reaction brings various cells to the injured site. They break down substances and proliferate to build up new bone or other types of tissues.

xHyA binds blood and promotes the formation of the blood clot. This effect helps the body in repairing tissue damage.

Support for regeneration

Various studies have shown that the additional administration of natural xHyA can, amongst others, lower inflammation and promote the formation of new blood vessels which is necessary for tissue regeneration. This considerably improves the healing process in terms of healing time and quantity of new tissue regeneration.

Wound space protection

A germ-free environment is a basic prerequisite for successful treatment in wound healing. Due to its pronounced bacterio- static property and slow resorption pattern, the xHyA gel prevents the penetration and growth of common oral pathogens, lowering the risk of re-infection.

Outcome after CLEAN vs After CLEAN&SEAL

  1. Bacteriostatic shield against oral bacteria
  2. Lower inflammation & better vascularization
  3. Resorbable xHyA: blood clot stabilization, and regeneration of cementum, periodontal ligament, bone & gingiva

Periodontitis after CLEAN&SEAL

What is hyaluronic acid?

Hyaluronic acid (HyA) is a physiological substance, chains of HyA are found in all living organisms. They are one of the main components of connective tissues, synovial fluid, and many other tissues. HyA play a variety of important roles in virtually all basic regenerative processes, such as wound healing and embryogenesis. In general, HyA is important in situations where rapid tissue regeneration and repair occurs.

Which hyaluronic acids are available?

The HyA molecule occurs in different forms in the body, which perform different functions. Depending on the desired area of application, hyaluronic acid is either used in its natural or in a cross-linked form.

Natural hyaluronic acid has the highest regenerative potential, but breaks down in the body within a few hours to a few days. To extend its retention time in the body, natural HyA can be cross- linked using proven technologies. With increasing cross-linking rate, the retention time can be extended to several months. However, cross-linked HyA does not promote regeneration as much as it functions more as a compatible filler material, e.g. in cosmetic applications for wrinkle injections. Therefore, a mix- ture of both natural and cross-linked HyA is advantageous as it offers the benefits of both substances.

  • 100% free from animal source materials for maximum protection against infection
  • Highest possible degree of purity for optimal biocompatibility
  • Clearly defined molecule size as a basic requirement for consistent product quality and optimal performance

Are side effects known?

Pure hyaluronic acid is the same for all species, which is why the occurrence of side effects is generally very unlikely. In individual cases, allergic reactions or intolerance reactions to hyaluronic acid may occur.

Are there alternatives to CLEAN&SEAL ?

Instead of using CLEAN&SEAL, your practitioner can perform the pocket treatment with mechanical cleaning only, i.e. without the additional use of auxiliaries.

It is also possible for your practitioner to use only one of the two preparations, i.e. either the CLEANER to support pocket cleaning or the SEALER to improve new tissue regeneration around the tooth/implant.

Alternatives to the CLEANER are preparations that aim to inactivate or remove the biofilm. These include local anti- biotics, antiseptic products (mostly based on chlorhexidine) or lasers.

Instead of the SEALER, extracts from the patient’s own blood or animal tooth proteins can be used. Additionally, there are other hyaluronic acid products of animal or biotechnological origin with different characteristics and material properties.

Your practitioner will assess the possible advantages and disadvantages, as well as the respective risks and consequences of the possible treatment options and will recommend an optimal therapy for you.