Tissue Regenerator

Product
Biologics
Indications
Guided tissue regeneration (GTR), Guided bone regeneration (GBR), Peri-implant / periodontal diseases
Size
2 x 1,2ml
Composition
Cross-linked hyaluronic acid

Why the hyaluronic acid gel Hyadent BG?

Hyadent BG is used for soft tissue recession surgery, guided tissue regeneration (GTR) as well as guided bone regeneration (GBR). The surgical-grade cross-linked hyaluronic acid-based gel of non-animal origin is optimized for regenerative peri-implant and periodontal applications.

  • Accelerated tissue healing – Coordinates the post-operative inflammation process and accelerates neoangiogenesis [1,2].
  • Improved outcome – Stabilizes coagulum and supports tissue regeneration[1-4].
  • Improved predictability – Bacteriostatic action and reduced pathogen penetration[5].

What does hyaluronic acid (HA) do?

HA empowers tissue regeneration

The mode of action of hyaluronic acid

mode of action of surgical-grade cross-linked hyaluronic acid (HA): Hyadent BG
  1. Attracts blood
  2. Stabilizes coagulum and supports tissue regeneration
  3. Bacteriostatic effect provides protection
  4. Growth factors attracted by hyaluronic acid
  5. Coordinates inflammation and accelerates angiogenesis

What is Hyadent BG?

  • Cross-linked hyaluronic acid gel (class III)
  • Cartridge.of non-animal origin
  • 2 x 1,2 ml ampulla
  • Store at room temperature (2 °C – 25 °C).

How to use Hyadent BG?

3 Minute Sticky Bone with Hyadent BG and Smartgraft.

Deep Miller Class II gingival recession (Prof A Sculean) with Hyadent BG

Infrabony defect (Prof A Pilloni) with Hyadent BG

GBR prior to implant placement (Prof D Bozic) with Hyadent BG and Smartbrane

Pocket sealing after biofilm removal of a case affected by mucositis (Dr M Roncati)

Soft tissue augmentation with Hyadent BG and Smartbrane (Dr M Pierchalla)

How does surgical-grade cross-linked hyaluronic acid work?

Hyadent BG, as a highly concentrated and cross-linked hyaluronic acid gel, is designed specifically for application in the field of dental surgery. HA, as one of the main components of the extracellular matrix, is naturally present in the human body [6-8]. Studies have shown that the prolonged presence of HA during the healing process promotes healing by regeneration rather than reparation [9,10].  Besides accelerating the healing of soft tissue and bone[11-13], the bacteriostatic properties of HA also protect the wound [5].

Cross-linked hyaluronic acid remains present throughout the various phases of the healing process due to its slow degradation pattern (several weeks) [14]. In addition, it aids the surgical periodontal treatment after application to the root surface and soft tissue. This leads to faster wound closure, substantial pocket reduction and enhanced attachment [1,3-4]. When mixed with bone substitute material, such as Smartgraft, of any origin Hyadent BG forms an easily manageable putty, which may, in addition, lead to accelerated bone formation [15,16].

Literature

  1. King SR, Hickerson WL, Proctor KG. Beneficial actions of exogenous hyaluronic acid on healing. Surgery 1991;109(1):76-84
  2. Kessiena L. Aya et al. ‘Hyaluronan in wound healing: Rediscovering a major player.’ Wound Rep Reg 2014;22:579-593. Dental Journal. (2017) Vol.42:104-
  3. Fawzy ES. et al. Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial. Clin Oral Invest 2012;16:1229-1236
  4. Briguglio, F. et al. Treatment of infrabony periodontal defects using a resorbable biopolymer of hyaluronic acid: A randomized clinical trial. Quintessence Int 2013;44:231-240
  5. Pirnazar P. et al. ’Bacteriostatic effects of hyaluronic acid.’ Journal of Periodontology 1999;70:370-374
  6. Lee JY, Spicer AP. ‘Hyaluronan: a multifunctional, megadalton, stealth molecule.’ Curr Opin Cell Biol 2000;12:581–586.
  7. McDonald J, Hascall VC. ‘Hyaluronan mini review series.’ JBiol Chem 2002; 277:4575–4579.
  8. Jiang D et al. ‘Hyaluronan as an immune regulator in human diseases.’ Physiol Rev 2011;91:221–264.
  9. Longaker T et al. ‘Studies in Fetal Wound Healing: V. A prolonged presence of hyaluronic acid characterizes fetal wound healing’ Ann. Surg. 1991; April:292–296.
  10. Mast BA et al. ‘Hyaluronic Acid Modulates Proliferation, Collagen and Protein Synthesis of Cultured Fetal Fibroblast’ Matrix, 1993;13:441–446.
  11. Salbach J et al. ‘Regenerative potential of glycosaminoglycans for skin and bone.’ J Mol Med 2012;90:625–635.
  12. Muzaffer A. et al. ‘The Effect of Hyaluronic Acid-supplemented Bone Graft in Bone Healing: Experimental Study in Rabbits ’ J Biomater Appl 2006 20:209
  13. Sasaki T, Watanabe C, Bone. Vol. 16. No.1 January 1995:9-15
  14. De Boulle K, Glogau R, Kono T, et al. ‚A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether– Crosslinked Hyaluronic Acid Dermal Fillers.’ Dermatologic Surgery 2013;39(12):1758-1766
  15. Stiller M. et al. ‘Performance of β-tricalcium phosphate granules and putty, bone grafting materials after bilateral sinus floor augmentation in humans’ Biomaterials 2014;35(10):3154-3163.
  16. Mendes RM et al. ‘Sodium hyaluronate accelerates the healing process in tooth sockets of rat’Arch Oral Biol 2008; 53:1155–1162
  17. Shirakata Y, Imafuji T, Nakamura T, Kawakami Y, Shinohara Y, Noguchi K, Pilloni A, Sculean A. Periodontal wound healing/regeneration of two-wall intrabony defects following reconstructive surgery with cross-linked hyaluronic acid-gel with or without a collagen matrix: a preclinical study in dogs. Quintessence Int. 2021;0(0):308-316. doi: 10.3290/j.qi.b937003.

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