PERISOLV – Biofilm Eraser

WHY USE A BIOFILM ERASER IN PERIODONTAL AND PERI-IMPLANT TREATMENT ?

Elimination of the biofilm is key for the treatment success of periodontitis, peri-implant muscositis and peri-implantitis.

  • Elimination of the biofilm [1]
  • Improvement of peri-implant situations such as mucositis [2]
  • Reduction of pocket depth [3,4]

Periodontitis, peri-implant mucositis, and peri-implantitis are bacterial inflammations with similar symptoms. The underlying cause behind all three indications, which progress in a similar way, is bacterial plaque forming a biofilm, rich in pathogenic bacteria. The softening of the biofilm and effective elimination of the bacteria is the key prerequisite for the successful treatment of these conditions.

Mode of action of sodium hypochlorite gel with amino acid (Perisolv) in periodontal procket. Removal of biofilm.

HOW DOES THE PERISOLV BIOFILM ERASER WORK ?

PERISOLV, as a biofilm eraser, is a debridement gel used in addition to mechanical debridement. When hypochlorite sodium is activated with amino acids and applied to the biofilm, even in locations hard to reach, the solution alters the biofilm’s matrix. It enhances bacterial removal by mechanical debridement [5] and facilitates its removal.

This biofilm eraser is effective in treating root surfaces and allows for PDL cell survival, attachment, and spreading onto all root surfaces [6]. It improves clinical parameters [7-10] as well as helps to control inflammation [9-10].

HOW TO USE THE BIOFILM ERASER PERISOLV ?

CASE REPORT : MUCOSITIS TREATED WITH PERISOLV (AND HYADENT BG)

Treatment of mucositis by Dr Marisa Roncati with PERISOLV to remove the biofilm

CASE REPORT : FURCATION TREATED WITH PERISOLV

Treatment of a furcation defect with PERISOLV by Prof Vincenzo Iorio-Siciliano, University of Catanzaro, Italy

CASE REPORT : PERIODONTAL POCKETS WITH PERISOLV

Non-surgical treatment of residual periodontal pocket with PERISOLV by Prof Dr Stefan Fickl University of Würzburg, Germany

SCIENTIFIC LITERATURE & CLINICAL STUDIES

  1. NB: Enhancing bacterial removal by mechanical debridement.
  2. Iorio-Siciliano V, Blasi A, Stratul SI, Ramaglia L, Sculean A, Salvi GE, Rusu D. Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial. Clin Oral Investig. 2020 Jun;24(6):1971-1979. doi: 10.1007/s00784-019-03060-2. Epub 2019 Aug 21. PMID: 31432311.
  3. Guarnelli ME et al. ‘Professional local administration of chloramine-based treatment in conjunction with ultrasonic mechanical instrumentation: clinical outcomes in patients with deep periodontal pockets persisting following active non-surgical therapy’. Minerva Stomatologia, April 2015; Vol. 64 suppl. 1 al No. 2: 158-159.
  4. Data on file.
  5. Jurczyk K, Nietzsche S, Ender C, Sculean A, Eick S. In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis. Clin Oral Investig. 2016;20(8):2165-2173. doi:10.1007/s00784-016-1711-9
  6. Schmidlin PR, Fujioka-Kobayashi M, Mueller HD, Sculean A, Lussi A, Miron RJ. Effects of air polishing and an amino acid buffered hypochlorite solution to dentin surfaces and periodontal ligament cell survival, attachment, and spreading. Clin Oral Investig. 2017;21(5):1589-1598. doi:10.1007/s00784-016-1950-9
  7. Iorio-Siciliano V, Ramaglia L, Isola G, Blasi A, Salvi GE, Sculean A. Changes in clinical parameters following adjunctive local sodium hypochlorite gel in minimally invasive nonsurgical therapy (MINST) of periodontal pockets: a 6-month randomized controlled clinical trial. Clin Oral Investig. 2021 Sep;25(9):5331-5340. doi: 10.1007/s00784-021-03841-8. Epub 2021 Mar 9. PMID: 33687555; PMCID: PMC8370947.
  8. Mayer Y, Ginesin O, Horwitz J. A nonsurgical treatment of peri-implantitis using mechanic, antiseptic and anti-inflammatory treatment: 1 year follow-up. Clin Exp Dent Res. 2020 Aug;6(4):478-485. doi: 10.1002/cre2.286. Epub 2020 Mar 17. PMID: 32185910; PMCID: PMC7453777.
  9. Radulescu V, Boariu MI, Rusu D, Roman A, Surlin P, Voicu A, Didilescu AC, Jentsch H, Siciliano VI, Ramaglia L, Vela O, Kardaras G, Sculean A, Stratul SI. Clinical and microbiological effects of a single application of sodium hypochlorite gel during subgingival re-instrumentation: a triple-blind randomized placebo-controlled clinical trial. Clin Oral Investig. 2022 Nov;26(11):6639-6652. doi: 10.1007/s00784-022-04618-3. Epub 2022 Jul 12. PMID: 35829773.
  10. Diehl, D.; Friedmann, A.; Liedloff, P.; Jung, R.M.; Sculean, A.; Bilhan, H. Adjunctive Application of Hyaluronic Acid in Combination with a Sodium Hypochlorite Gel for Non-Surgical Treatment of Residual Pockets Reduces the Need for Periodontal Surgery—Retrospective Analysis of a Clinical Case Series. Materials 2022, 15, 6508. https:// doi.org/10.3390/ma15196508